General Seminars

The Role of Mitochondrial Quality Control and Stress Signalling in Parkinson's Disease

by Nicoleta Moisoi (Health and Life Sciences, Leicester School of Pharmacy, De Montfort University, Leicester, UK)

Tuesday, 22 November 2016 from to (Europe/Bucharest)
at National Library of Physics
Parkinson’s Disease (PD) has a multifactorial ethiopathology. Aging, genetic susceptibility and environmental factors are recognised as key factors contributing to its occurrence. Two main signaling pathways are involved in PD pathogenesis, namely, mitochondrial quality control (MQC) and protein aggregation. Components of these signaling cascades have been found mutated in PD and by studying them we aim to understand disease mechanisms and to uncover novel pharmacological approaches to tackle disease progression.
Reinforcement of specialised mechanisms that maintain mitochondrial
homeostasy is thus critical particularly in Parkinson's. Here I will present characteristics of molecular and organellar MQC signaling pathways and their role in PD ethiopathogenesis. Moreover I will present the possibility to activate MQC genetically and pharmacologically to compensate for PD related mitochondrial dysfunction.