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  4. Gheorghe Necula

Gheorghe Necula

DFCTI

3505 /

george.necula@nipne.ro

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25

Scientific Articles

29

Conferences

2

Books

.

Patents

  1. Tuning phosphorene and MoS2 2D materials for detecting volatile organic compounds associated with respiratory diseases
    2. Alaa Allosh, Calin-Andrei Pantis-Simut, Nicolae Filipoiu, Amanda Teodora Preda, George Necula, Ioan Ghitiu, Dragos-Victor Anghel, Mihnea Alexandru Dulea and George Alexandru Nemne

    RSC Adv., 2024, 14, 1803

  2. Interaction of Tryptophan- and Arginine-Rich Antimicrobial Peptide with E. coli Outer Membrane—A Molecular Simulation Approach
    3. George Necula, Mihaela Bacalum and Mihai Radu

    Int. J. Mol. Sci. 2023, 24(3), 2005

  3. Melittin Induces Local Order Changes in Artificial and Biological Membranes as Revealed by Spectral Analysis of Laurdan Fluorescence
    4. Bogdan Zorilă, George Necula, Mihai Radu and Mihaela Bacalum

    Toxins 2020, 12, 705; doi:10.3390/toxins12110705

  4. Characterization of post-pandemic influenza virus circulation in southern region of Romania during 2010-2014
    5. Necula G, Popovici O, Manuc D, Munteanu AM

    INFECTION GENETICS AND EVOLUTION

  5. Short tryptophan- and arginine-rich peptide shows efficacy against clinical methicillin-resistant Staphylococcus aureus strains isolated from skin and soft tissue infections
    6. Bacalum M, Dragulescu E-C, Necula G, Codita I, Radu M.

    Sci Rep

  6. Updating RoNBio molecular modelling system to support in silico investigation of AMP activity on membrane models
    7. G. Necula, L. Janosi, M. Bacalum, M. Radu

    Grid, Cloud & High Performance Computing in Science (ROLCG), Conference

  7. In silico validation of NorA homology model from S. aureus using FEP and Metadynamics
    8. G. Necula

    Eur. Biophys. J. Vol. 46, Supplement 1, Iulie 2017, pag. S225

  8. Epidemiological and molecular investigation of a rubella outbreak, Romania, 2011 to 2012
    9. Lazar M, Abernathy E, Chen MH, Icenogle J, Janta D, Stanescu A, Pistol A, Santibanez S, Mankertz A, Hübschen JM, Mihaescu G, Necula G, Lupulescu E.

    Euro Surveill. 2016 Sep 22;21(38)

  9. Vaccine effectiveness in preventing laboratory-confirmed influenza in primary care patients in a season of co-circulation of influenza A(H1N1)pdm09, B and drifted A(H3N2), I-MOVE Multicentre Case-Control Study, Europe 2014/15.
    10. Valenciano M, Kissling E, Reuss A, Rizzo C, Gherasim A, Horváth JK, Domegan L, Pitigoi D, Machado A, Paradowska-Stankiewicz IA, Bella A, Larrauri A, Ferenczi A; Joan O´Donell, Lazar M, Pechirra P, Korczyńska MR, Pozo F, Moren A, Buda S, Prahm K, Schweiger B, Wedde M, Biere B, Oroszi B, Herczegh É, Giese C, Alfonsi V, Castrucci MR, Puzzeli S, Rodrigues A, Guiomar R, Costa I, Cristóvão P, lupulescu E, Ivanciuc AE, Cherciu CM, Mihai ME, Tecu C, Necula G, Altzíbar J, Cenoz MG, Lozano J, Martínez-Ochoa E, Vanrell J, Castrillejo D.

    Euro Surveill. 2016;21(7):pii=30139

  10. Circulating influenza viruses and the effectiveness of seasonal influenza vaccine in Romania, season 2012-2013
    11. Daniela Pitigoi, George Necula, Viorel Alexandrescu, Maria Elena Mihai, Carmen Maria Cherciu, Cristina Tecu, Odette Popovici, Rodica Popescu, Emilia Lupulescu

    Revista Română de Medicină de Laborator Vol. 23, Nr. 1, Martie, 2015

  11. The European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2)
    12. Valenciano M, Kissling E, Reuss A, Jiménez-Jorge S, Horváth JK, Donnell JM, Pitigoi D, Machado A, Pozo F, Moren A, Buchholz U, Buda S, Prahm K, Schweiger B, Wedde M, Oroszi B, Domegan LM, Giese C, Guiomar R, Pechirra P, Lupulescu E, Necula G, Mihai ME, Cherciu CM, Alexandrescu V, Larrauri A, García Cenoz M, González-Carril F, Martínez-Ochoa E, Vega T, Giménez-Durán J, Castrillejo D

    Vaccine. 2015 Jun 4;33(24):2813-22

  12. DIFFERENTIATION OF INFLUENZA B LINEAGES FROM CLINICAL SAMPLES BY ONE-STEP REAL-TIME RT-PCR
    13. Carmen Maria Cherciu, Gheorghe Necula, Maria Elena Mihai, Alina Elena Ivanciuc, Mihaela lazar, Cristina Tecu, Daniela Piþigoi, Emilia Lupulescu

    Roum Arch Microbiol Immunol. 73 (2014) 25-29

  13. Influenza vaccine effectiveness estimates in Europe in a season with three influenza type/subtypes circulating: the I-MOVE multicentre case-control study, influenza season 2012/13
    14. E Kissling, M Valenciano, U Buchholz, A Larrauri, J M Cohen, B Nunes, J Rogalska, D Pitigoi, I Paradowska-Stankiewicz, A Reuss, S Jiménez-Jorge, I Daviaud, R Guiomar, J O’Donnell, G Necula, M Głuchowska, A Moren

    Eurosurveillance 19 (2014) 22-33

  14. Low and decreasing vaccine effectiveness against influenza A(H3) in 2011/12 among vaccination target groups in Europe: results from the I-MOVE multicentre case-control study
    15. E Kissling, M Valenciano, A Larrauri, B Oroszi, J M Cohen, B Nunes, D Pitigoi, C Rizzo, J Rebolledo, I Paradowska-Stankiewicz, S Jiménez-Jorge, J K Horváth, I Daviaud, R Guiomar, G Necula, A Bella, J O’Donnell, M Głuchowska, B C Ciancio, A Nicoll, A Moren

    Eurosurveillance 18 (2013) 33-42

  15. Single and multipathogen viral infections in hospitalized children with acute respiratory infections
    16. Tecu C, Mihai ME, Alexandrescu VI, Orăşeanu D, Zapucioiu C, Ivanciuc AE, Necula G, Lupulescu E, Chiriţă D, Piţigoi D

    Roum Arch Microbiol Immunol. 72 (2013) 242-249

  16. Transmission and molecular characterisation of wild measles virus in Romania, 2008 to 2012
    17. G Necula, M Lazar, A Stanescu, A Pistol, S Santibanez, A Mankertz, E Lupulescu

    Eurosurveillance 18 (2013) 28-37

  17. Viral Respiratory Infections with Bocavirus in Romania
    18. Tecu C, Mihai ME, Alexandrescu V, Ivanciuc A, Necula G, Lupulescu E, Popovici O

    J Medical Microbiol Diagnosis S1: 006. doi:10.4172/2161-0703.S1-006

  18. Influenza vaccine effectiveness to prevent medically attended laboratory confirmed influenza during season 2010-2011 in Romania: a case control study
    19. D Pitigoi, AEIvanciuc, G Necula, E Lupulescu, A Alexandrescu, C Savulescu

    REV ROMANA MED LAB 20 (2012) 127-134

  19. Severe acute respiratory infections surveillance in Romania - is it any gain to public health?
    20. Nicolae O, Popovici F, Lupulescu E, Ivanciuc AE, Necula G

    Rev Med Chir Soc Med Nat Iasi. 116 (2012) 1185-91

  20. ONGOING MEASLES OUTBREAK IN ROMANIA, 2011
    21. A Stanescu, D Janta, E Lupulescu, G Necula, M Lazar, G Molnar, A Pistol

    EUROSURVEILLANCE 16 (2011) 4-7

  21. Overview of influenza virus antiviral resistance in Romania in the last four epidemic seasons - phenotyping, genotyping and molecular analysis study
    22. Necula G, Mihai ME, Sbarcea CE, Dinu S, Lupulescu E, Ceausu E, Streinu-Cercel A, Mihailescu DF, Alexandrescu VI

    REV ROMANA MED LAB 19 (2011) 227-240

  22. Spread of Measles Virus D4-Hamburg, Europe, 2008-2011
    23. Annette Mankertz, Zefira Mihneva, Hermann Gold, Sigrid Baumgarte, Armin Baillot, Rudolph Helble, Hedwig Roggendorf, Golubinka Bosevska, Jasminka Nedeljkovic, Agata Makowka, Veronik Hutse, Heidemarie Holzmann, Stefan W. Aberle, Samuel Cordey, Gheorghe Necula, Andreas Mentis, Gulay Korukluoğlu, Michael Carr, Kevin E. Brown, Judith M. Hübschen, Claude P. Muller, Mick N. Mulders, Sabine Santibanez

    EMERG INFECT DIS 17 (2011) 1396-1401

  23. Survival of H5N1 influenza virus in water and its inactivation by chemical methods
    24. Mihai ME, Tecu C, Ivanciuc AE, Necula G, Lupulescu E, Onu A

    Roum Arch Microbiol Immunol. 70 (2011) 78-84

  24. Spotlight on measles 2010: An ongoing measles outbreak in the district of Neamt, Romania, August-September 2010
    25. A Stanescu, M Muscat, A Romaniuc, R Pipirigeanu, E Lupulescu, G Necula, M Lazar, G Molnar, A Pistol

    EUROSURVEILLANCE 15 (2010) 4-6

  25. Investigation of the influence of different physico-chemical parameters upon the susceptibility of planktonic and adherent Escherichia coli cells to beta-lactams and quinolones
    26. Dracea O, Iordache C, Bucur M, Bleotu C, Banu O, Ungureanu C, Cristea D, Lixandru M S, Larion Cristina, Necula G, Lazar V, Chifiriuc M C

    Roumanian archives of microbiology and immunology

  1. Optimization of active layers based on graphene-like materials for binding biomarkers used in respiratory disease diagnostication
    2. Alaa Allosh, Calin Pantis, Nicolae Filipoiu, Amanda Preda, George Necula, Dragos-Victor Anghel, George Alexandru Nemnes

    TURKISH PHYSICAL SOCIETY 39TH INTERNATIONAL PHYSICS CONGRESS, BODRUM, TURKEY, AUGUST 31 – SEPTEMBER 4, 2023 (2023)

  2. In Silico Modeling of a Short Arginine and Tryptophan-based Antimicrobial Peptides Interaction with Bacterial and Mammalian Membranes
    3. Lorant Janosi, George Necula, Alexandra Farcas, Ioan Turcu

    International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental Sciences, Brasov, Romania, 08 - 10 June, 2022 (2022)

  3. INTERACTION OF AN TRYPTOPHAN- AND ARGININE-RICH ANTIMICROBIAL PEPTIDE WITH E. COLI OUTER MEMBRANE - A MOLECULAR SIMULATION APPROACH
    4. George Necula, Mihaela Bacalum and Mihai Radu

    17th NATIONAL CONFERENCE OF BIOPHYSICS WITH INTERNATIONAL PARTICIPATION, Targu Mures, Romania, 23-25 September 2022 (2022)

  4. Extending the RoNBio Molecular Modelling System Capacity for In Silico Investigation of AMP Activity on Membrane Models
    5. eorge Necula, Mihaela Bacalum, Lorant Janosi, Mihai Radu

    National Online Conference of Biophysics 2020, Braşov, 14th – 16th June, 2020 (2020)

  5. Application of the fragment molecular orbital George Necula method to the investigation of antimicrobial peptides interaction with membrane models
    6. Necula G

    International Conference on Advanced Scientific Computing (2019)

  6. Investigation of binding energies of histidine-modulated arginine and tryptophan-based peptides in membrane models: In silico and spectroscopic studies
    7. Janosi L, Zorila B, Necula G, Bacalum M, Radu M, Turcu I.

    Joint 12th EBSA European Biophysics Congress / 10th IUPAP International Conference on Biological Physics (ICBP) (2019)

  7. In silico studies on the dynamics and energetics of histidine-modulated arginine- and tryptophan-based peptides in membrane models
    8. Lorant Janosi, George Necula, Mihaela Bacalum, Mihai Radu, Ioan Turcu,

    IC-ANMBES 2018, 23 - 25 May, 2018 Brasov, Romania (2018)

  8. RoNBio: A molecular modelling system for computational biology updated to support the investigation of AMP activity on membrane models
    9. George Necula, Lorant Janosi, Mihaela Bacalum, Mihai Radu

    XV National Conference of Romanian Society of Pure and applied Biophysics, 07 - 09 September 2018 Bucharest, Romania (2018)

  9. Updating RoNBio molecular modelling system to support in silico investigation of AMP activity on membrane models
    10. George Necula, Lorant Janosi, Mihaela Bacalum, Mihai Radu

    2018 Conference Grid, Cloud & High Performance Computing in Science (ROLCG 2018), 17-19 Octomber, Cluj-Napoca, IEEE conferences (2018)

  10. Genetic Characterization of influenza A(H3N2) viruses in Romania during 2016-2017 influenza season
    11. Lazăr M, Pitigoi D, Cherciu C, Mihai M.E, Necula G, Ivanciuc A, Lupulescu E.

    13th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, 08-10 November 2017, ISSN 2457-8525, p42 (2017)

  11. In silico validation of NorA homology model from S. aureus using FEP and Metadynamics
    12. G. Necula

    19th IUPAB and 11th EBSA Congress Edingurgh, Scotland, 16-20 July, 2017 (2017)

  12. Monitorizarea eficacitatii vaccinului antigripal sezonier si pandemic in Europa. Proiectul I-MOVE (Influenza Monitoring Vaccine Effectiveness)
    13. Pitigoi D, Ivanciuc A, Lazăr M, Cherciu C, Mihai M.E, Necula G, Tecu C, Lupulescu E.

    a 47-a Conferință Anuală de Imunologie cu participare internațională, 4 - 6 Octombrie 2017, Bucuresti, Romanaia ISBN 978-606-8003-71-9 (2017)

  13. RoNBio: A molecular modeling system for computational biology
    14. George Necula, Dragoş Ciobanu-Zabet, Ionuţ Vasile, Dorin Simionescu, Maria Mernea, Mihnea Dulea

    Grid, Cloud and High-Performance Computing in Science 26-28 October 2017 Sinaia, Prahova (2017)

  14. Caracterizarea genetică a virusurilor gripale A(H1N1)pdm09 circulante în România în sezonul 2015/16
    15. Alina Elena Ivanciuc, Mihaela Lazăr, Carmen Maria Cherciu, Maria Elena Mihai, Cristina Ţecu, Daniela Piţigoi, Gheorghe Necula, Rodica Popescu, Odette Popovici, Emilia Lupulescu

    A IX-a Conferinţă Naţională de Microbiologie şi Epidemiologie, 20-22 octombrie 2016, Brașov (2016)

  15. In silico validation of NorA homology model from Staphylococcus aureus using Molecular Dynamics and Free Energy Perturbation
    16. George Necula

    16th Annual European User Meeting, London, England, 21-23 September 2016 (2016)

  16. Integration of HTC and HPC tools for solving complex problems in computational biology
    17. Dragoş Ciobanu-Zabet, Dragoş Honţ, George Necula, Ionuţ Vasile, Mihnea Dulea

    RO-LCG 2016, Bucharest-Magurele, 26-28 October 2016 (2016)

  17. Testarea sensibilităţii virusurilor gripale la antivirale printr-o tehnică fluorescentă
    18. Maria Elena Mihai, Carmen Maria Cherciu, Alina Elena Ivanciuc, Cristina Ţecu, Gh. Necula, Gr. Mihăescu, Emilia Lupulescu

    A IX-a Conferinţă Naţională de Microbiologie şi Epidemiologie, 20-22 octombrie 2016, Brașov (2016)

  18. Construction and validation of a NorA efflux pump homology model that can be used to identify new inhibitors
    19. Gheorghe Necula, Dragos Ciobanu-Zabet, Mihnea Dulea

    Conferință Națională de Biofizică (CNB 2015), cu participare internațională, 4-6 iunie, 2015, Timişoara, Romania. (2015)

  19. Genetic characterization and phylogenetic analysis of human influenza A (H3N2) viruses in two consecutive seasons
    20. Mihaela Lazar, Alina Ivanciuc, Gheorghe Necula, Emilia Lupulescu

    11TH EDITION OF THE SCIENTIFIC DAYS OF THE NATIONAL INSTITUTE OF INFECTIOUS DISEASES “PROF.DR. MATEI BALŞ” BUCHAREST, 14-16 OCTOBER 2015 (2015)

  20. Molecular structure prediction of NorA multidrug transporter from Staphylococcus aureus
    21. Gheorghe Necula, Dragos Ciobanu-Zabet, Mihnea Dulea

    10th European Biophysics Congress, July 18 to 22, 2015 in Dresden, Germany (2015)

  21. Monitoring influenza viruses’ genetic data: A touchstone in understanding the virus-host interaction and in selection of seasonal influenza vaccine’s strains
    22. Mihaela Lazar, Alina Elena Ivanciuc, Carmen Maria Cherciu, Gheorghe Necula, Daniela Pitigoi, Odette Popovici, Rodica Popescu, Maria Elena Mihai, Cristina Tecu, Emilia Lupulescu

    International Conference on Influenza, August 24-26, 2015 London, UK (2015)

  22. Particularities of circulating influenza viruses between 2010 – 2014 in the southern part of Romania
    23. George Necula, Lucian Lerescu, Elena Alina Ivanciuc, Carmen Maria Cherciu, Claudiu Edward Sbârcea, Emilia Lupulescu

    4th International Symposium on Adipobiology and Adipopharmacology (2015)

  23. Modeling the drug-protein interaction on DFCTI HPC platform
    24. Gheorghe Necula, Dragos Ciobanu-Zabet

    RO-LCG 2014 Conference Grid, Cloud & High Performance Computing in Physics Research (2014)

  24. A case report of type A (subtype H1N1 pandemic 2009) and type B influenza virus dual infection in 2012-2013 season
    25. Lupulescu E, Necula G, Mihai ME, Dinu S, Tecu C, Pitigoi D, Alexandrescu V

    The 6th Romanian Conference of Microbiology and Epidemiology, Bucharest, Romania, November 14-16 2013 (2013)

  25. Seasonal influenza vaccine effectiveness in Romania: results from the case-control study, 2012/2013
    26. Pitigoi D, Lupulescu E, Alexandrescu V, Ivanciuc AE, Mihai M, Necula G

    2013 European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) Stockholm, Sweden, November 5-7, 2013 (2013)

  26. Influenza vaccine effectiveness in Romania 2011/2012: results of a case-control study
    27. Pitigoi D, Lupulescu E, Alexandrescu V, Ivanciuc AE, Necula G, Mihai ME, Savulescu C

    ESCAIDE, Edinburgh, UK, 24-26 Oct 2012 (2012)

  27. Is influenza vaccine effective? Results of three Romanian IMOVE case-control studies, 2008-2012
    28. Pitigoi D, Alexandrescu V, Ivanciuc AE, Mihai ME, Necula G, Savulescu C, Sbarcea C, Lupulescu E

    THE SCIENTIFIC DAYS OF THE NATIONAL INSTITUTE OF INFECTIOUS DISEASES "MATEI BALS" BUCHAREST, 17-19 OCTOBER 2012 (2012)

  28. Synthesis of Silver Nanoparticles using Alkylpolyglucoside
    29. Achimescu D, Spiroiu MF, Peretz S, Anghel DF, Dinescu DF, Necula G, Cherciu C, Lupulescu E

    THE 10th INTERNATIONAL CONFERENCE ON COLLOIDS AND SURFACES CHEMISTRY, Galati, Iunie 2011 (2011)

  29. Analiza genetica a virusului gripal pandemic 2009 In România
    30. Necula G, Dinu S, Sbarcea C, Lupulescu E

    A II-a Conferinta Nationala de Microbiologie si Epidemiologie, Sinaia, ROMANIA, 14-16 Octombrie 2010 (2010)

  1. Research Advances in Microbiology and Biotechnology Vol. 5, Chapter 8 - Studies on Viral Respiratory Infections with Bocavirus in Romania, ed. Prof. Francisco Cruz Sosa (B P International), 2023, pp. 136-143
    2. Cristina Tecu, Maria Elena Mihai, Viorel Alexandrescu, Alina Ivanciuc, Gheorghe Necula, Emilia Lupulescu and Odette Popovici

    2023

  2. Updating RoNBio molecular modelling system to support in silico investigation of AMP activity on membrane models
    3. George Necula, Lorant Janosi, Mihaela Bacalum, Mihai Radu

    2018

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